thrombopoietin receptor agonist

Indications

• treatment of immune-mediated thrombocytopenia

Contraindications

• chemotherapy-induced thrombocytopenia

Mechanism of action

• stimulates platelet production via thrombopoietin receptor

More general terms

• receptor agonist
• hematologic agent

More specific terms

• avatrombopag (Doptelet)
• eltrombopag (AKR-501, Promacta)
• lusutrombopag (Mulpleta)
• romiplostim (AMG531, Nplate)
• thrombopoietin; megakaryocyte colony stimulating factor; C-MPL ligand; megakaryocyte growth & development factor (MGDF, THPO)

Additional terms

• thrombopoietin receptor; TPO-R; myeloproliferative leukemia protein; C-mpl; CD110 (MPL, TPOR)