interleukin-15 (IL15, IL-15)

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Function

stimulates the proliferation of T-cell
- requires interaction of IL-15 with components of IL-2R, including IL-2R beta & IL-2R gamma but NOT IL-2R alpha.

Compartment

IL15-S48AA: secreted
IL15-S21AA: cytoplasm, nucleus, NOT secreted

Alternative splicing

named isoforms=3

Expression

expressed in placenta, skeletal muscle > heart, lung, liver, kidney
IL15S21AA is preferentially expressed in testis, thymus

More general terms

Additional terms

interleukin-15 receptor

References

↑ Taniguchi T Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716517
↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3600
↑ UniProt http://www.uniprot.org/uniprot/P40933.html
↑ R&D systems' cytokine source book: IL-15 http://www.rndsystems.com/molecule_detail.aspx?m=1671
↑ Wikipedia; Note: interleukin-15 entry http://en.wikipedia.org/wiki/interleukin_15

Database

Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3600
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3600
OMIM: https://mirror.omim.org/entry/600554
UniProt: http://www.uniprot.org/uniprot/P40933.html

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