SOCS box domain

Introduction

C-terminal domain of about 50 amino acid residues composed of 2 blocks of well-conserved residues separated by 2-10 nonconserved residues. The C-terminal conserved region is a Leu & Pro-rich sequence of unknown function; the N-terminal conserved region is termed a 'BC box' & binds to the elongin BC complex.

May couple proteins to ubiquitination or proteasomal catabolism.

First identified in cytokine-inducible SH2-containing protein (SOCS) family.

Also found in:

• WSB (WD-40-repeat-containing protein with a SOCS box) family
• SSB (SPRY domain-containing protein with a SOCS box) family
• ASB (Ankyrin-repeat-containing protein with a SOCS box) family
• RAR (GTPase domain & SOCS box-containing protein) family.

More general terms

• peptide motif
• domain