leptin; obesity factor; obese protein (LEP, OB, OBS)
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Function
- regulation of:
- body weight/fat metabolism
- hematopoiesis
- angiogenesis
- wound healing
- inflammatory & immune response
- bone mineral density (increases)
Expression
- secreted by adipocytes
- circadian rhythm; highest plasma levels at 2 AM
Pathology
- leptin gene mutation associated with autosomal recessive obesity
- higher plasma leptin associated with lower risk of AD[3]
More general terms
Additional terms
References
- ↑ Gerotological Society, Annual Meeting, Boston MA, Nov 2002
- ↑ OMIM https://mirror.omim.org/entry/164160
- ↑ 3.0 3.1 Lieb W et al. Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA 2009 Dec 16; 302:2565. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20009056
- ↑ UniProt http://www.uniprot.org/uniprot/P41159.html
- ↑ R&D systems' cytokine mini-reviews: leptin http://www.rndsystems.com/molecule_detail.aspx?m=1773
- ↑ Wikipedia; Note: leptin entry http://en.wikipedia.org/wiki/leptin
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/lep/
Database
- OMIM: https://mirror.omim.org/entry/164160
- OMIM: https://mirror.omim.org/entry/601694
- OMIM: https://mirror.omim.org/entry/601665
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3952
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3952
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7839
- UniProt: http://www.uniprot.org/uniprot/P41159.html