vinexin; SH3-containing adapter molecule 1; SCAM-1; sorbin & SH3 domain-containing protein 3 (SORBS3, SCAM1)

Function

• vinexin alpha isoform promotes up-regulation of actin stress fiber formation
• vinexin beta isoform plays a role in cell spreading & enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain
• interacts with DLG5 through its third SH3 domain
• interacts with vinculin by the first two SH3 domains & the proline rich region of vinculin
• binds to SOS (guanine nucleotide exchange factor of RAS & RAC), through its third SH3 domain; formation of this complex is down-regulated by phosphorylation of SOS
• interacts with INPPL1/SHIP2, SAFB2, SOCS7 & SRCIN1

Structure

• contains 3 SH3 domains
• contains 1 SoHo domain

Compartment

• isoform alpha:
  • cell junction
  • cytoplasm, cytoskeleton (putative)
  • localized at cell-extracellular matrix junctions
• isoform beta:
  • cell junction (putative)
  • nucleus
  • cytoplasm, cytoskeleton (putative)
  • localized at cell-extracellular matrix junctions (putative)
• both isoforms localized at focal adhesion & cell-cell adhesion sites

Alternative splicing

named isoforms=2; alpha, beta

Expression

• both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle & pancreas
• isoform beta is especially found in liver

More general terms

• cytoskeletal protein
• phosphoprotein

Additional terms

• son of sevenless homolog protein (SOS)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10174
• OMIM: https://mirror.omim.org/entry/610795
• UniProt: http://www.uniprot.org/uniprot/O60504.html