p130Cas-associated protein; p140Cap; SNAP-25-interacting protein; SNIP; P140 (SRCIN1, KIAA1684)

Function

• delays the onset of cell spreading in the early stages of cell adhesion to fibronectin
• role in Ca+2-dependent exocytosis from PC12 cells
• interacts with the N-terminal coiled-coil region of SNAP25 (putative)
• interacts with BCAR1/p130Cas through its C-terminal domain
• Tyr-phosphorylated in response to EGF & to cell adhesion to integrin ligands

Structure

belongs to the p140Cap family

Compartment

• cytoplasm, cytoskeleton
• localized to the perinuclear region, lamellopodia, cortical actin & actin stress fibers but not to focal adhesions

Alternative splicing

named isoforms=3

More general terms

• cytoskeletal protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9C0H9.html