disks large homolog 5; discs large protein P-dlg; placenta & prostate DLG (DLG5, KIAA0583, PDLG)

Function

• plasma membrane, maintenance of epithelial cells
• transmission of extracellular signals to membrane & cytoskeleton
• interacts with MPP1
• interacts with CTNNB1 & SORBS3 (3rd domain) to form a ternary complex

Structure

• belongs to the MAGUK family
• contains 1 guanylate kinase-like domain
• contains 4 PDZ domain (DHR domain)s
• contains 1 SH3 domain

Compartment

• plasma membrane
• cell-cell junction, sites of cell-cell contact

Alternative splicing

named isoforms=5

Expression

• expressed in the placenta, prostate > thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver, kidney
• a short splice product shows more limited expression, being absent from at least the brain

More general terms

• cytoskeletal protein
• phosphoprotein

Additional terms

• discs large homolog
• disks large-associated protein 1; DAP-1; guanylate kinase-associated protein; hGKAP; SAP90/PSD-95-associated protein 1; SAPAP1; PSD-95/SAP90-binding protein 1 (DLGAP1 DAP1 GKAP)
• drosophila discs large [dlg] protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9231
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9231
• OMIM: https://mirror.omim.org/entry/604090
• UniProt: http://www.uniprot.org/uniprot/Q8TDM6.html