guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)

Introduction

Facilitates exchange of GDP for GTP in guanine nucleotide regulatory proteins (GNRP).

                  GDS
GNRP ... GDP     ----->   GNRP ... GTP

 (inactive)                 (active)

More general terms

• enzyme

More specific terms

• A-kinase anchor protein 13; AKAP-13; AKAP-Lbc; breast cancer nuclear receptor-binding auxiliary protein; guanine nucleotide exchange factor Lbc; human thyroid-anchoring protein 31; lymphoid blast crisis oncogene; LBC oncogene; non-oncogenic Rho GTPase-...
• ABI1/EPS8/SOS1 complex
• active breakpoint cluster region-related protein (ABR)
• ALS2 C-terminal-like protein (ALS2CL)
• ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein, ANKRD27)
• brefeldin A-inhibited guanine nucleotide-exchange protein 1; brefeldin A-inhibited GEP 1; p200 ARF-GEP1; p200 ARF guanine nucleotide exchange factor (ARFGEF1, ARFGEP1, BIG1)
• brefeldin A-inhibited guanine nucleotide-exchange protein 2; brefeldin A-inhibited GEP 2 (ARFGEF2, ARFGEP2, BIG2)
• brefeldin A-inhibited guanine nucleotide-exchange protein 3 (ARFGEF3, BIG3, KIAA1244)
• cdc24 protein
• cdc25 protein
• cytohesin ADP Ribosylation Factor (ARF) nucleotide binding site opener (ARNO)
• dbl/MCF2 proto-oncogene protein (MCF2, DBL)
• Dedicator of cytokinesis protein 11 (Zizimin-2, activated Cdc42-associated guanine nucleotide exchange factor, ACG, DOCK11, ZIZ2)
• DEP domain-containing protein 2 (phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2, PtdIns(3,4,5)-dependent Rac exchanger 2, P-Rex2, DEPDC2, PREX2)
• differentially expressed in FDCP 6 (DEF-6, IRF4-binding protein, DEF6, IBP)
• drosophila son of sevenless protein
• E3 ubiquitin-protein ligase HERC1 (HECT domain & RCC1-like domain-containing protein 1, p532, p619, HERC1)
• elongation factor 1-beta (EEF1B2)
• elongation factor 1-delta (EEF1D)
• elongation factor 1-epsilon (multisynthetase complex auxiliary component p18, elongation factor p18, EEF1E1)
• ephexin (eph interacting exchange factor)
• eukaryotic initiation factor 2B
• eukaryotic initiation factor 2C
• FERM, RhoGEF & pleckstrin domain-containing protein 2 (FERM domain including RhoGEF, FIR, FARP2, KIAA0793)
• FERM, RhoGEF and pleckstrin domain-containing protein 1 (chondrocyte-derived ezrin-like protein, FARP1, CDEP)
• FYVE, RhoGEF & PH domain-containing protein 1; faciogenital dysplasia 1 protein; zinc finger FYVE domain-containing protein 3; Rho/Rac guanine nucleotide exchange factor FGD1; Rho/Rac GEF (FGD1, FGDY, ZFYVE3)
• FYVE, RhoGEF & PH domain-containing protein 4 (actin filament-binding protein frabin, FGD1-related F-actin-binding protein, zinc finger FYVE domain-containing protein 6, FGD4, FRABP, ZFYVE6)
• G-protein coupled receptor; serpentine receptor
• GRIP1-associated protein 1; GRASP-1 (GRIPAP1 ,KIAA1167)
• GTPase-activating protein & VPS9 domain-containing protein 1 (Rab5-activating protein 6, GAPex-5, GAPVD1, GAPEX5, KIAA1521 RAP6)
• guanine nucleotide exchange factor DBS; DBL's big sister; MCF2-transforming sequence-like protein (MCF2L, KIAA0362)
• guanine nucleotide exchange factor FLJ41603 (ARHGEF37)
• guanine nucleotide exchange factor for Rab3A (Rab3A-interacting-like protein 1, Rabin3-like , RAB3IL1)
• guanine nucleotide exchange factor GEFT; RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT, Rac/Cdc42/Rho exchange factor GEFT; p63RhoGEF (GEFT, ARHGEF25)
• guanine nucleotide exchange factor LFDH; lung-specific F-box & DH domain-containing protein (LFDH, ECT2L, C6orf91)
• guanine nucleotide exchange factor MCF2L2 (MCF2-transforming sequence-like protein 2, Dbs-related Rho family guanine nucleotide exchange factor, MCF2L2, DRG, KIAA0861)
• guanine nucleotide exchange factor MSS4 (Rab-interacting factor, RABIF, MSS4, RASGRF3, mammalian suppressor of sec4)
• IQ motif & Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100, ADP-ribosylation factors guanine nucleotide-exchange protein 2, brefeldin-resistant Arf-GEF 2 protein, IQSEC1, ARFGEP100, BRAG2, KIAA0763)
• kalirin; huntingtin-associated protein-interacting protein; protein duo; serine/threonine protein kinase with Dbl- & pleckstrin homology domain (KALRN, DUET, DUO, HAPIP, TRAD)
• PH & SEC7 domain-containing protein 1 (pleckstrin homology & SEC7 domain-containing protein 1, exchange factor for ARF6, PSD, EFA6, KIAA2011, PSD1, TYL)
• PH & SEC7 domain-containing protein 4 (pleckstrin homology & SEC7 domain-containing protein 4, exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B, telomeric of interleukin-1 cluster protein, PSD4, EFA6B, TIC)
• phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; P-Rex1; Ptdins(3,4,5)-dependent Rac exchanger 1 (PREX1, KIAA1415)
• prolactin regulatory element-binding protein; mammalian guanine nucleotide exchange factor msec12 (PREB, SEC12)
• protein RCC2 (telophase disk protein of 60 kD, RCC1-like protein TD-60, RCC2, KIAA1470, TD60)
• protein SOLO (SOLO, ARHGEF40)
• protein very KIND (kinase non-catalytic C-lobe domain-containing protein 1, KIND domain-containing protein 1, Ras-GEF domain-containing family member 2, cerebral protein 9, KNDC1, C10orf23, KIAA1768, RASGEF2, VKIND, hucep-9)
• Ral guanine nucleotide dissociation stimulator-like 1; RalGDS-like 1 (RGL1, KIAA0959, RGL)
• Ral guanine nucleotide dissociation stimulator-like 2; RalGDS-like 2; RalGDS-like factor; Ras-associated protein RAB2L (RGL2, RAB2L)
• ral guanine nucleotide exchange factor (ral-GEF, RALGDS)
• Ral-GDS-related protein (RGL4, RGR)
• rap guanine nucleotide exchange factor 1; guanine nucleotide-releasing factor 2; C3G protein; CRK SH3-binding GNRP (RAPGEF1 GRF2)
• Rap guanine nucleotide exchange factor 2 (PDZ domain-containing guanine nucleotide exchange factor 1, neural RAP guanine nucleotide exchange protein, nRap GEP, PDZ-GEF1, RA-GEF, RAPGEF2, KIAA0313, NRAPGEP, PDZGEF1)
• rap guanine nucleotide exchange factor 3; cAMP-regulated guanine nucleotide exchange factor I; cAMP-GEFI; exchange factor directly activated by cAMP 1; exchange protein directly activated by cAMP 1; EPAC 1; rap1 guanine-nucleotide-exchange factor direc...
• rap guanine nucleotide exchange factor 4; exchange factor directly activated by cAMP 2; exchange protein directly activated by cAMP 2; EPAC 2; cAMP-regulated guanine nucleotide exchange factor II; cAMP-GEFII (RAPGEF4, CGEF2, EPAC2)
• Rap guanine nucleotide exchange factor 5 (guanine nucleotide exchange factor for Rap1, related to Epac, Repac, M-Ras-regulated Rap GEF, MR-GEF, RAPGEF5, GFR, KIAA0277, MRGEF)
• Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2, PDZ-GEF2, RA-GEF-2, RAPGEF6, PDZGEF2)
• rap guanine nucleotide exchange factor-like 1; link guanine nucleotide exchange factor II; link GEFII (RAPGEFL1)
• rap1 GTPase-GDP dissociation stimulator 1; SMG GDS protein; SMG P21 stimulatory GDP/GTP exchange protein; exchange factor smgGDS (RAP1GDS1)
• ras guanine nucleotide releasing factor 1; Ras-specific guanine nucleotide-releasing factor 1; Ras-GRF1; guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25 (RASGRF1, CDC25, GNRP, GRF1)
• RAS guanyl-releasing protein 1 (Ras guanyl-releasing protein, Ca+2 & DAG-regulated guanine nucleotide exchange factor II, calDAG-GEFII, RASGRP1, RASGRP)
• RAS guanyl-releasing protein 2 (Ca+2 & DAG-regulated guanine nucleotide exchange factor I, CalDAG-GEFI, F25B3.3 kinase-like protein, Cdc25-like protein, HCDC25L, RASGRP2, CDC25L, MCG7)
• RAS guanyl-releasing protein 3 (Ca+2 DAG-regulated guanine nucleotide exchange factor 3, guanine nucleotide exchange factor for Rap1)
• RAS guanyl-releasing protein 4 (RASGRP4)
• Ras-GEF domain-containing family member 1A (RASGEF1A)
• Ras-GEF domain-containing family member 1B (GPI gamma-4, RASGEF1B, GPIG4)
• Ras-GEF domain-containing family member 1C (RASGEF1C)
• Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2, guanine nucleotide-releasing factor 2, Ras guanine nucleotide exchange factor 2, RASGRF2, GRF2)
• Ras-specific guanine nucleotide-releasing factor RalGPS1 (RalA exchange factor RalGPS1, Ral GEF with PH domain & SH3-binding motif 1, RALGPS1, KIAA0351, RALGEF2)
• Ras-specific guanine nucleotide-releasing factor RalGPS2 (RalA exchange factor RalGPS2, Ral GEF with PH domain & SH3-binding motif 2) (RALGPS2)
• regulator of chromosome condensation; chromosome condensation protein 1; cell cycle regulatory protein (RCC1, CHC1)
• rho guanine nucleotide exchange factor
• Rho guanine nucleotide exchange factor 10-like protein (grinchGEF, ARHGEF10L, GRINCHGEF, KIAA1626)
• Rho guanine nucleotide exchange factor 18 (114 kD Rho-specific guanine nucleotide exchange factor, p114-Rho-GEF, p114RhoGEF, septin-associated RhoGEF, SA-RhoGEF, ARHGEF18, KIAA0521)
• Rho guanine nucleotide exchange factor 19 (ARHGEF19)
• Rho guanine nucleotide exchange factor 5-like protein (ARHGEF35)
• Rho guanine nucleotide exchange factor FLJ20184 (ARHGEF38)
• RPGR-interacting protein 1; X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGRIP1)
• Sdc25 protein
• secretion-regulating guanine nucleotide exchange factor (guanine nucleotide exchange factor-related protein, deafness locus-associated putative guanine nucleotide exchange factor, DelGEF, SERGEF, DELGEF, GNEFR)
• SH2 domain-containing protein 3C (Novel SH2-containing protein 3, SH2D3C, NSP3, UNQ272/PRO34088/PRO309)
• SH3 domain-containing guanine exchange factor (SGEF, ARHGEF26)
• son of sevenless homolog protein (SOS)
• switch-associated protein 70 (SWAP-70, SWAP70, KIAA0640, HSPC321)
• synembryn-A (protein Ric-8A, RIC8A)
• synembryn-B (brain synembrin, hSyn, protein Ric-8B)
• T-cell lymphoma invasion & metastasis 2 (TIAM2)
• T-lymphoma invasion & metastasis-inducing protein 1; TIAM-1 (TIAM1)
• triple functional domain protein (PTPRF-interacting protein, TRIO)
• VAV-like protein C9orf100 (ARHGEF39)
• X-linked retinitis pigmentosa GTPase regulator (RPGR, RP3, XLRP3)

Additional terms

• guanine nucleotide regulatory protein (GNRP)