guanine nucleotide exchange factor MCF2L2 (MCF2-transforming sequence-like protein 2, Dbs-related Rho family guanine nucleotide exchange factor, MCF2L2, DRG, KIAA0861)

Function

• probably functions as guanine nucleotide exchange factor

Structure

• belongs to the MCF2 family
• contains 1 CRAL-TRIO domain
• contains 1 DH (DBL-homology) domain
• contains 1 PH domain
• contains 1 spectrin repeat

Alternative splicing

named isoforms=4

Expression

• expressed in brain > pancreas, brain & testis

Pathology

• genetic variation in MCF2L2 may be associated with susceptibility to diabetes mellitus type-2

More general terms

• guanine nucleotide exchange factor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2310
• OMIM: https://mirror.omim.org/entry/125853
• UniProt: http://www.uniprot.org/uniprot/Q86YR7.html