FERM, RhoGEF & pleckstrin domain-containing protein 2 (FERM domain including RhoGEF, FIR, FARP2, KIAA0793)

Function

• Rho-guanine nucleotide exchange factor
• activates RAC1
• role in response to class 3 semaphorins & remodeling of actin cytoskeleton
• interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity
• dissociates from PLXNA1 when SEMA3A binds to receptor
• interacts with PIP5K1C via its FERM domain
• interaction with PIP5K1C enhanced byvSEMA3A binding

Structure

• contains 1 DH domain (DBL-homology domain)
• contains 1 FERM domain
• contains 2 PH domains

Alternative splicing

named isoforms=2

More general terms

• guanine nucleotide exchange factor

Database

• UniProt: http://www.uniprot.org/uniprot/O94887.html