semaphorin-3A; semaphorin III; sema III (SEMA3A SEMAD)

Function

• induces the collapse & paralysis of neuronal growth cones
• may serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism
• binds to the complex neuropilin-1/plexin-1 (putative)
• in mice, simultaneously promotes bone formation & inhibits bone resorption

Structure

• strong binding to neuropilin is mediated by the C-terminal 3rd of the protein
• belongs to the semaphorin family
• contains 1 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 PSI domain
• contains 1 sema domain

Compartment

secreted (putative)

More general terms

• secreted protein
• glycoprotein
• semaphorin or semaphorin/collapsin family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10371
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10371
• OMIM: https://mirror.omim.org/entry/603961
• UniProt: http://www.uniprot.org/uniprot/Q14563.html