plexin-A1; semaphorin receptor NOV (PLXNA1, NOV, PLXN1)

Function

• coreceptor for SEMA3A, SEMA3C, SEMA3F & SEMA6D.
• signaling by class 3 semaphorins*
• remodelling of cytoskeleton
• axon guidance
• invasive growth
• cell migration
• interacts with NRP1, NRP2, FARP2, RND1, VEGFR2
• binding of SEMA3A leads to dissociation of FARP2

* class 3 semaphorins bind to a complex composed of a neuropilin & a plexin; the plexin modulates affinity of the complex for specific semaphorins

Structure

• belongs to the plexin family
• contains 4 IPT/TIG domains
• contains 1 Sema domain

Compartment

membrane

Expression

expressed in fetal brain, lung, liver, kidney

More general terms

• plexin A
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5361
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5361
• OMIM: https://mirror.omim.org/entry/601055
• UniProt: http://www.uniprot.org/uniprot/Q9UIW2.html