Semaphorin-6D (SEMA6D, KIAA1479)

Function

• growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro
• may be a stop signal for DRG neurons in their target areas, & possibly also for other neurons
• role in maintenance & remodeling of neuronal connections

Structure

• belongs to the semaphorin family
• contains 1 PSI domain
• contains 1 Sema domain

Compartment

isoforms 1-5: cell membrane isoform 7: cytoplasm

Alternative splicing

named isoforms=7

More general terms

• semaphorin or semaphorin/collapsin family protein
• membrane protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80031
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80031
• OMIM: https://mirror.omim.org/entry/609295
• UniProt: http://www.uniprot.org/uniprot/Q8NFY4.html