PH & SEC7 domain-containing protein 4 (pleckstrin homology & SEC7 domain-containing protein 4, exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B, telomeric of interleukin-1 cluster protein, PSD4, EFA6B, TIC)

Function

• guanine nucleotide exchange factor for ARF6-like protein
• role in membrane recycling

Structure

• contains 1 PH domain
• contains 1 SEC7 domain

Compartment

• cell membrane
• accumulates in dynamic actin-rich membrane ruffles & microvilli-like structures

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highest levels of expression in placenta, pancreas, spleen, thymus & peripheral blood

More general terms

• guanine nucleotide exchange factor
• PH & SEC7 domain-containing protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NDX1.html