Dedicator of cytokinesis protein 11 (Zizimin-2, activated Cdc42-associated guanine nucleotide exchange factor, ACG, DOCK11, ZIZ2)

Function

• guanine nucleotide-exchange factor (GEF)
• activates CDC42 by exchanging bound GDP for free GTP
• interacts with CDC42 (putative)
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• DHR-2 domain is necessary for the GEF activity
• belongs to the DOCK family
• contains 1 DHR-1 (CZH-1) domain
• contains 1 DHR-2 (CZH-2) domain
• contains 1 PH domain

Notes

'Zizim' means 'spike' in Hebrew

More general terms

• phosphoprotein
• guanine nucleotide exchange factor
• dedicator of cytokinesis protein (DOCK)

Database

• UniProt: http://www.uniprot.org/uniprot/Q5JSL3.html