Ras-specific guanine nucleotide-releasing factor RalGPS2 (RalA exchange factor RalGPS2, Ral GEF with PH domain & SH3-binding motif 2) (RALGPS2)

Function

• guanine nucleotide exchange factor for the small GTPase RalA.
• may be involved in cytoskeleton organization
• may also be nvolved in the stimulation of transcription (Ras-independent)
• interacts with SH3 domain of GRB2 & PLCG1

Structure

• PH domain mediates binding to PIP2
• contains 1 PH domain
• contains 1 Ras-GEF domain

Compartment

• cytoplasm, cell membrane
• associated with membranes through PH domain

Alternative splicing

named isoforms=2

Pathology

• defects in RALGPS2 gene may be a cause of Alzheimer disease

More general terms

• phosphoprotein
• guanine nucleotide exchange factor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5510
• UniProt: http://www.uniprot.org/uniprot/Q86X27.html