guanine nucleotide exchange domain (Ras-GEF, Ras exhange motif)

Introduction

Sequence similarity shared by guanine nucleotide dissociation stimulators of about 250 amino acids generally located in the C-terminal section region of the molecule.

Function

• promotes the loss of bound GDP and the uptake of fresh GTP

More general terms

• catalytic domain

Additional terms

• guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)