rap guanine nucleotide exchange factor 1; guanine nucleotide-releasing factor 2; C3G protein; CRK SH3-binding GNRP (RAPGEF1 GRF2)

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^[1]^[2]^[3]

Function

guanine nucleotide-releasing protein
binds to SH3 domain of CRK & GRB2/ASH
transduces signals from CRK to activate RAS
interacts with CRK via its SH3-binding sites

Structure

contains 1 N-terminal Ras-GEF domain
contains 1 Ras-GEF domain

Alternative splicing

named isoforms=2

Expression

ubiquitously expressed in adult & fetus
expression is high in adult skeletal muscle & placenta & in fetal brain & heart
low levels of expression in adult & fetal liver

More general terms

Additional terms

ras signal transduction

References

↑ Pawson T. Protein modules and signalling networks. Nature. 1995 Feb 16;373(6515):573-80. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822
↑ Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7716514
↑ UniProt http://www.uniprot.org/uniprot/Q13905.html

Database

Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2889
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2889
OMIM: https://mirror.omim.org/entry/600303
UniProt: http://www.uniprot.org/uniprot/Q13905.html

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