ras signal transduction
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Introduction
see figure: signalling via tyrosine kinase receptor see figure: signalling via src family protein
Biochemistry
- ras signal 1
- substrate: Grb2 protein + Sos protein
- product: grb2-sos complex
- ras signal 1a
- substrate: c-crk protein + Sos1 protein
- product: molecular complex - subunits: c-crk protein - motif: SH2-domain SH3-domain - site: central - qualities: intermolecular_bond - effector-bound: Sos1 protein - bound-via: proline-rich region (C-terminal) SH3-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: Sos1 protein - bound-via: proline-rich region (C-terminal)* Sos1 protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: c-crk protein - bound-via: SH3-domain (central) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: c-crk protein - bound-via: SH3-domain (C-terminal)
- ras signal 1b
- substrate: c-crk protein + ras GNEF-C3G
- product: molecular complex - subunits: c-crk protein - motif: SH2-domain SH3-domain - site: central - qualities: intermolecular bond - effector-bound: ras GNEF-C3G - bound-via: proline-rich region - site: PR-a SH3-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: ras GNEF-C3G - bound-via: proline-rich region - site: PR-b ras GNEF-C3G - motif: proline-rich region - site: PR-a - qualities: intermolecular bond - effector-bound: c-crk protein - bound-via: SH3-domain (central) proline-rich region - site: PR-b - qualities: intermolecular bond - effector-bound: c-crk protein - bound-via: SH3-domain (C-terminal)
- ras signal 2a
- enzyme: tyrosine phosphatase
- substrate: src-family protein (inactive)
- product: src-family protein (active)
- ras signal 2b
- substrate: c-src protein (active) + SHC-transforming protein-1
- product: molecular complex - subunits: c-src protein - motif: phospho-Tyr site (phosphorylated) - site: Y416 - qualities: intermolecular bond SHC-transforming protein-1 - motif: SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: c-src protein (active) - bound-via: phospho-Tyr site (phosphorylated) - site: Y416
- ras signal 2c
- substrate: insulin receptor (active) - subunits: insulin receptor-alpha (2) - motif: ligand-binding site - effector-bound: insulin insulin receptor-beta (2) - motif: phospho-Tyr site (phosphorylated) SHC-transforming protein-1
- product: molecular complex - subunits: insulin receptor (active) - subunits: insulin receptor-alpha (2) - motif: ligand-binding site - effector-bound: insulin insulin receptor-beta (2) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond SHC-transforming protein-1 - motif: SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: insulin receptor-beta (active) - bound-via: phospho-Tyr site (phosphorylated)
- ras signal 2d
- enzyme: molecular complex - subunits: insulin receptor (active) - subunits: insulin receptor-alpha (2) - motif: ligand-binding site - effector-bound: insulin insulin receptor-beta (2) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond SHC-transforming protein-1 - motif: SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: insulin receptor-beta (active) - bound-via: phospho-Tyr site (phosphorylated)
- substrate: molecular complex - subunits: insulin receptor (active) - subunits: insulin receptor-alpha (2) - motif: ligand-binding site - effector-bound: insulin insulin receptor-beta (2) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond SHC-transforming protein-1 - motif: SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: insulin receptor-beta :state active - bound-via: phospho-Tyr site (phosphorylated)
- product: molecular complex - subunits: insulin receptor (active) - subunits: insulin receptor-alpha (2 - motif: ligand-binding site - effector-bound: insulin insulin receptor-beta (2) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond SHC-transforming protein-1 - motif: phospho-Tyr site (phosphorylated) several SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: insulin receptor-beta :state active - bound-via: phospho-Tyr site (phosphorylated)
- ras signal 3
- enzyme: molecular complex - subunits: c-src protein - motif: phospho-Tyr site (phosphorylated) - site: Y416 - qualities: intermolecular bond SHC-transforming protein-1 - motif: SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: c-src protein (active) - bound-via: phospho-Tyr site (phosphorylated) - site: Y416
- substrate: molecular complex - subunits: c-src protein - motif: phospho-Tyr site (phosphorylated) - site: Y416 - qualities: intermolecular bond SHC-transforming protein-1 - motif: SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: c-src protein (active) - bound-via: phospho-Tyr site (phosphorylated) - site: Y416
- product: molecular complex - subunits: c-src protein - motif: phospho-Tyr site (phosphorylated) - site: Y416 - qualities: intermolecular bond SHC-transforming protein-1 - motif: phospho-Tyr site (phosphorylated) several SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: c-src protein (active) - bound-via: phospho-Tyr site (phosphorylated) - site: Y416
- ras signal 4
- substrate: grb2/Sos complex + molecular complex - subunits: c-src protein - motif: phospho-Tyr site (phosphorylated) - site: Y416 - qualities: intermolecular bond SHC-transforming protein-1 - motif: phospho-Tyr site (phosphorylated) several SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: c-src protein (active) - bound-via: phospho-Tyr site (phosphorylated) - site: Y416
- product: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: c-src protein - motif: phospho-Tyr site (phosphorylated) - site: Y416 - qualities: intermolecular bond SHC-transforming protein-1 - motif: phospho-Tyr site (phosphorylated) several SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: c-src protein (active) - bound-via: phospho-Tyr site (phosphorylated) - site: Y416 GRB2 protein - motif: SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal) - site: N-terminal SH2-domain - qualities: intermolecular bond - effector-bound: SHC-transforming protein-1 - bound-via: phospho-Tyr site (phosphorylated) - site: unspecified SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal)* - site: C-terminal Sos protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: GRB2 protein - bound-via: SH3-domain (N-terminal) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: GRB2 protein - bound-via: SH3-domain (C-terminal)
- ras signal 4b
- substrate: grb2/Sos complex) molecular complex - subunits: insulin receptor (active) - subunits: insulin receptor-alpha (2) - motif: ligand-binding site - effector-bound: insulin insulin receptor-beta (2) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond SHC-transforming protein-1 - motif: phospho-Tyr site (phosphorylated) several SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: insulin receptor-beta (active) - bound-via: phospho-Tyr site (phosphorylated)
- product: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: insulin receptor (active) - subunits: insulin receptor-alpha (2) - motif: ligand-binding site - effector-bound: insulin insulin receptor-beta (2) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond SHC-transforming protein-1 - motif: phospho-Tyr site (phosphorylated) several SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: insulin receptor-beta (active) - bound-via: phospho-Tyr site (phosphorylated) GRB2 protein - motif: SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal) - site: N-terminal) SH2-domain - qualities: intermolecular bond - effector-bound: SHC-transforming protein-1 - bound-via: phospho-Tyr site (phosphorylated) SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal)* - site: C-terminal Sos protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: GRB2 protein - bound-via: SH3-domain (N-terminal) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: GRB2 protein - bound-via: SH3-domain (C-terminal)
- ras signal 5
- enzyme: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: c-src protein - motif: phospho-Tyr site (phosphorylated) - site: Y416 - qualities: intermolecular bond SHC-transforming protein-1 - motif: phospho-Tyr site (phosphorylated) several SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: c-src protein (active) - bound-via: phospho-Tyr site (phosphorylated) - site: Y416 GRB2 protein - motif: SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal) - site: N-terminal SH2-domain - qualities: intermolecular bond - effector-bound: SHC-transforming protein-1 - bound-via: phospho-Tyr site (phosphorylated) - site: unspecified SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal)* - site: C-terminal Sos protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: GRB2 protein - bound-via: SH3-domain (N-terminal) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: GRB2 protein - bound-via: SH3-domain (C-terminal)
- substrate: p21ras(GDP) + GTP
- product: p21ras(GTP) + GDP
- ras signal 5b
- enzyme: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: insulin receptor (active) - subunits: insulin receptor-alpha (2) - motif: ligand-binding site - effector-bound: insulin insulin receptor-beta (2) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond SHC-transforming protein-1 - motif: phospho-Tyr site (phosphorylated) several SH2-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: insulin receptor-beta (active) - bound-via: phospho-Tyr site (phosphorylated) GRB2 protein - motif: SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal) - site: N-terminal SH2-domain - qualities: intermolecular bond - effector-bound: SHC-transforming protein-1 - bound-via: phospho-Tyr site (phosphorylated) SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal)* - site: C-terminal Sos protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: GRB2 protein - bound-via: SH3-domain (N-terminal) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: GRB2 protein - bound-via: SH3-domain (C-terminal)
- substrate: p21ras(GDP) + GTP
- product: p21ras(GTP) + GDP
- ras signal 6
- substrate: grb2/Sos_complex + tyrosine kinase receptor (active) - motif: phospho-Tyr site (phosphorylated)
- product: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: tyrosine kinase receptor (active) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond GRB2 protein - motif: SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal) - site: N-terminal SH2-domain - qualities: intermolecular bond - effector-bound: EGF receptor - bound-via: phospho-Tyr site (phosphorylated) SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal)* - site: C-terminal Sos protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: GRB2 protein - bound-via: SH3-domain (N-terminal) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: GRB2 protein - bound-via: SH3-domain (C-terminal)
- ras signal 6c
- substrate: molecular complex - subunits: c-crk protein - motif: SH2-domain SH3-domain - site: central - qualities: intermolecular bond - effector-bound: Sos1 protein - bound-via: proline-rich region (C-terminal) SH3-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: Sos1 protein - bound-via: proline-rich region (C-terminal)* Sos1 protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: c-crk protein - bound-via: SH3-domain (central) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: c-crk protein - bound-via: SH3-domain (C-terminal) + tyrosine kinase receptor (active) - motif: phospho-Tyr site (phosphorylated)
- product: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: tyrosine kinase receptor (active) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond c-crk protein - motif: SH2-domain - qualities: intermolecular bond - effector-bound: tyrosine_kinase_receptor - bound-via: phospho-Tyr site (phosphorylated) SH3-domain - site: central - qualities: intermolecular bond - effector-bound: Sos1 protein - bound-via: proline-rich region (C-terminal) SH3-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: Sos1 protein - bound-via: proline-rich region (C-terminal)* Sos1 protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: c-crk protein - bound-via: SH3-domain (central) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: c-crk protein - bound-via: SH3-domain (C-terminal)
- ras signal 6d
- substrate: molecular complex - subunits: c-crk protein - motif: SH2-domain SH3-domain - site: central - qualities: intermolecular bond - effector-bound: ras GNEF-C3G - bound-via: proline-rich region - site: PR-a SH3-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: ras GNEF-C3G - bound-via: proline-rich region - site: PR-b ras GNEF-C3G - motif: proline-rich region - site: PR-a - qualities: intermolecular bond - effector-bound: c-crk protein - bound-via: SH3-domain (central) proline-rich region - site: PR-b - qualities: intermolecular bond - effector-bound: c-crk protein - bound-via: SH3-domain (C-terminal) + tyrosine kinase receptor (active) - motif: phospho-Tyr site (phosphorylated)
- product: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: tyrosine kinase receptor (active) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond c-crk protein - motif: SH2-domain - qualities: intermolecular bond - effector-bound: tyrosine_kinase_receptor - bound-via: phospho-Tyr site (phosphorylated) SH3-domain - site: central - qualities: intermolecular bond - effector-bound: ras GNEF-C3G - bound-via: proline-rich region - site: PR-a SH3-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: ras GNEF-C3G - bound-via: proline-rich region - site: PR-b ras GNEF-C3G - motif: proline-rich region - site: PR-a - qualities: intermolecular bond - effector-bound: c-crk protein - bound-via: SH3-domain (central) proline-rich region - site: PR-b - qualities: intermolecular bond - effector-bound: c-crk protein - bound-via: SH3-domain (C-terminal)
- ras signal 7
- enzyme: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: tyrosine kinase receptor (active) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond GRB2 protein - motif: SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal) - site: N-terminal) SH2-domain - qualities: intermolecular bond - effector-bound: EGF receptor - bound-via: phospho-Tyr site (phosphorylated) SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal)* - site: C-terminal Sos protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: GRB2 protein - bound-via: SH3-domain (N-terminal) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: GRB2 protein - bound-via: SH3-domain (C-terminal)
- ras signal 7c
- enzyme: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: tyrosine kinase receptor (active) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond c-crk protein - motif: SH2-domain - qualities: intermolecular bond - effector-bound: tyrosine_kinase_receptor - bound-via: phospho-Tyr site (phosphorylated) SH3-domain - site: central - qualities: intermolecular bond - effector-bound: Sos1 protein - bound-via: proline-rich region (C-terminal) SH3-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: Sos1 protein - bound-via: proline-rich region (C-terminal)* Sos1 protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: c-crk protein - bound-via: SH3-domain (central) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: c-crk protein - bound-via: SH3-domain (C-terminal)
- ras signal 7d
- enzyme: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: tyrosine kinase receptor (active) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond c-crk protein - motif: SH2-domain - qualities: intermolecular bond - effector-bound: tyrosine_kinase_receptor - bound-via: phospho-Tyr site (phosphorylated) SH3-domain - site: central - qualities: intermolecular bond - effector-bound: ras GNEF-C3G - bound-via: proline-rich region - site: PR-a SH3-domain - site: C-terminal - qualities: intermolecular bond - effector-bound: ras GNEF-C3G - bound-via: proline-rich region - site: PR-b ras GNEF-C3G - motif: proline-rich region - site: PR-a - qualities: intermolecular bond - effector-bound: c-crk protein - bound-via: SH3-domain (central) proline-rich region - site: PR-b - qualities: intermolecular bond - effector-bound: c-crk protein - bound-via: SH3-domain (C-terminal)
- ras signal 8
- substrate: p21ras (GTP) + molecular complex - compartment: cytoplasm - subunits: raf1 kinase (inactive) hsp90 protein (50 kD)
- product: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: p21ras (GTP) raf1 kinase (active) hsp90 protein (50 kD)
- ras signal 9
- enzyme: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: p21ras (GTP) raf1 kinase (active) hsp90 protein (50 kD)
- substrate: MAP kinase activator (inactive) - motif: phospho-Ser/Thr site (unphosphorylated)
- product: MAP kinase activator
- ras signal 10
- enzyme: MAP kinase activator
- substrate: MAP kinase (inactive) - motif: phospho-Thr site (unphosphorylated) - site: T183 phospho-Tyr site (phosphorylated) - site: Y185
- product: MAP kinase (active) - motif: phospho-Thr site (phosphorylated) - site: T183 phospho-Tyr site (phosphorylated) - site: Y185
- ras signal 6a
- substrate: molecular complex - compartment: cytoplasm - subunits: GRB2 protein - motif: SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal) - site: N-terminal SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal)* - site: C-terminal Sos protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: GRB2 protein - bound-via: SH3-domain (N-terminal) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: GRB2 protein - bound-via: SH3-domain (C-terminal) + EGF receptor (active dimer) - motif: phospho-Tyr site (phosphorylated)
- product: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: EGF receptor (active) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond GRB2 protein - motif: SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal) - site: N-terminal) SH2-domain - qualities: intermolecular bond - effector-bound: EGF receptor - bound-via: phospho-Tyr site (phosphorylated) SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal)* - site: C-terminal Sos protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: GRB2 protein - bound-via: SH3-domain (N-terminal) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: GRB2 protein - bound-via: SH3-domain (C-terminal)
- ras signal 6b
- substrate: molecular complex - compartment: cytoplasm - subunits: GRB2 protein - motif: SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal) - site: N-terminal SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal)* - site: C-terminal Sos protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: GRB2 protein - bound-via: SH3-domain (N-terminal) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: GRB2 protein - bound-via: SH3-domain (C-terminal) PDGF receptor-beta (active) - motif: phospho-Tyr site (phosphorylated)
- product: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: PDGF receptor-beta (active) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond GRB2 protein - motif: SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal) - site: N-terminal SH2-domain - qualities: intermolecular bond - effector-bound: EGF receptor - bound-via: phospho-Tyr site (phosphorylated) SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal)* - site: C-terminal Sos protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: GRB2 protein - bound-via: SH3-domain (N-terminal) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: GRB2 protein - bound-via: SH3-domain (C-terminal)
- ras signal 7a
- enzyme: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: EGF receptor (active) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond GRB2 protein - motif: SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal) - site: N-terminal) SH2-domain - qualities: intermolecular bond - effector-bound: EGF receptor - bound-via: phospho-Tyr site (phosphorylated) SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal)* - site: C-terminal Sos protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: GRB2 protein - bound-via: SH3-domain (N-terminal) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: GRB2 protein - bound-via: SH3-domain (C-terminal)
- ras signal 7b
- enzyme: molecular complex - compartment: plasma membrane (cytoplasmic face) - subunits: PDGF receptor-beta (active) - motif: phospho-Tyr site (phosphorylated) - qualities: intermolecular bond GRB2 protein - motif: SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal) - site: N-terminal) SH2-domain - qualities: intermolecular bond - effector-bound: EGF receptor - bound-via:phospho-Tyr site (phosphorylated) SH3-domain - qualities: intermolecular bond - effector-bound: Sos protein - bound-via: proline-rich region (C-terminal)* - site: C-terminal Sos protein - motif: proline-rich region - qualities: intermolecular bond - site: C-terminal - effector-bound: GRB2 protein - bound-via: SH3-domain (N-terminal) proline-rich region - qualities: intermolecular bond - site: C-terminal* - effector-bound: GRB2 protein - bound-via: SH3-domain (C-terminal)
More general terms
Additional terms
References
- ↑ Pawson Nature 373:573 1995
- ↑ Egan et al Nature 363:45 1993
- ↑ Baltensperger K, Kozma LM, Cherniack AD, Klarlund JK, Chawla A, Banerjee U, Czech MP. Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes. Science. 1993 Jun 25;260(5116):1950-2. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8391166
- ↑ Skolnik EY, Batzer A, Li N, Lee CH, Lowenstein E, Mohammadi M, Margolis B, Schlessinger J. The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science. 1993 Jun 25;260(5116):1953-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8316835
- ↑ Saltiel FASEB J 8:1034 1994
- ↑ Marx Science 260:1588 1993
- ↑ Hall Science 264:1413 1994
- ↑ Kyriakis et al. Nature 358:417-21 1992
- ↑ Lange-Carter et al Science 260:315 1993