raf1 proto-oncogene protein
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Function
- both cytosolic & membrane bound raf1 are found in large (300-500 kD) complexes that include 2 chaperones, hsp90 & p50
- Raf1 kinase may be activated by GTP-bound p21ras & by protein kinase C[8]
- Raf1 interacts with 14-3-3-beta & 14-3-3-zeta through its Zn finger[8]
Compartment
cytoplasm, membrane
Expression
ubiquitously expressed
More general terms
Additional terms
References
- ↑ Moodie SA, Willumsen BM, Weber MJ, Wolfman A. Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase. Science. 1993 Jun 11;260(5114):1658-61. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8503013
- ↑ Zhang XF, Settleman J, Kyriakis JM, Takeuchi-Suzuki E, Elledge SJ, Marshall MS, Bruder JT, Rapp UR, Avruch J. Normal and oncogenic p21ras proteins bind to the amino- terminal regulatory domain of c-Raf-1. Nature. 1993 Jul 22;364(6435):308-13. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8332187
- ↑ Morrison DK, Heidecker G, Rapp UR, Copeland TD. Identification of the major phosphorylation sites of the Raf-1 kinase. J Biol Chem. 1993 Aug 15;268(23):17309-16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8349614
- ↑ Bonner et al Nucleic Acids Res 14:1009 1993
- ↑ Vojtek AB, Hollenberg SM, Cooper JA. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell. 1993 Jul 16;74(1):205-14. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8334704
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 986
- ↑ Hall A. A biochemical function for ras--at last. Science. 1994 Jun 3;264(5164):1413-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8197454
- ↑ 8.0 8.1 8.2 Aitken A. 14-3-3 proteins on the MAP. Trends Biochem Sci. 1995 Mar;20(3):95-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7709434