14-3-3 protein beta/alpha; protein kinase C inhibitor protein 1; KCIP-1; protein 1054 (YWHAB)

Function

• adapter protein implicated in the regulation of both general & specialized signaling pathways
• binds many protein, usually by recognition of a phospho-Ser or phospho-Thr motif
• binding generally results in the modulation of the activity of the binding partner
• isoform alpha differs from isoform beta in being phosphorylated (putative)
• isoform short contains a N-acetylmethionine at position 1
• interacts with SSH1 & TORC2/CRTC2

Structure

• homodimer
• belongs to the 14-3-3 family
• contains a N-acetylmethionine at position 1

Compartment

• cytoplasm
• melanosome

Alternative initiation

named isoforms=2

More general terms

• 14-3-3 protein (KCIP-1)
• enzyme inhibitor
• metalloprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7529
• OMIM: https://mirror.omim.org/entry/601289
• UniProt: http://www.uniprot.org/uniprot/P31946.html