target of rapamycin 2 complex (TORC2 complex)

Function

• regulates cell growth & survival in response to hormonal signals
• activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive
• seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors
• promotes serum-induced formation of stress-fibers or F-actin.
• role in AKT1 Ser-473 phosphorylation; this may facilitate phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1, a prerequisite for full activation
• may modulate the phosphorylation of PKCA
• mTORC2 regulates the phosphorylation of SGK1 at Ser-422
• modulates the phosphorylation of PRKCA on Ser-657
• may regulate actin cytoskeleton organization
• TORC2 complex does not bind to & is not sensitive to FKBP12-rapamycin (in contrast to mTORC1)

Structure

• subunits include mTOR/FRAP1, LST8/GBL, PRR5, RICTOR & MAPKAP1

More general terms

• molecular complex

Additional terms

• target of rapamycin 1 complex (TORC1 complex)