proline-rich protein 5 (PRR5)

Function

• role in regulation of PDGFRB expression & in modulation of PDGF signaling
• may act as a tumor suppressor in breast cancer
• component of the TORC2 complex
• binds directly to FRAP1 & RICTOR within the TORC2 complex

Alternative splicing

named isoforms=4

Expression

• most abundant in kidney & liver
• also highly expressed in brain, spleen, testis & placenta

Pathology

• overexpressed in several colorectal tumors

More general terms

• proline-rich protein

Additional terms

• submaxillary gland androgen-regulated protein 3 homolog A; proline-rich protein 5; proline-rich protein PBI (SMR3A, PBI, PROL5)

Database

• UniProt: http://www.uniprot.org/uniprot/P85299.html