FKBP12-rapamycin complex-associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1; rapamycin target protein; RAPT1; mammalian target of rapamycin; mTOR (FRAP1, FRAP, FRAP2)

Function

• role in cell cycle progression
• interacts with the FKBP12-rapamycin complex
• acts as the target for the cell-cycle arrest & immunosuppressive effects of the FKBP12-rapamycin complex
• rapamycin inhibits mTOR pathway
• component of the TORC1 complex
• component of the TORC2 complex
  • role in actin cytoskeleton organization
• binds directly to PRR5 & RICTOR within the TORC2 complex
• forms complex with raptor
• binds UBQLN1
• upstream regulator of HIF-1 in cancer cells
• downstream targets include S6K1 & 4EBP1/eIF4E
• inhibited by several natural products
  • tuberin
  • hamartin
  • curcumin
  • resveratrol
  • epigallocatechin gallate
  • caffeine

Structure

• belongs to the PI3/PI4-kinase family
• contains 1 FAT domain
• contains 1 FATC domain
• contains 7 HEAT repeats
• contains 1 PI3K/PI4K domain

Expression

• expressed in numerous tissues, with highest levels in testis

Notes

• inhibition of FRAPA1 & the TORC1 complex may account for some of the benefits of caloric restriction

More general terms

• protein kinase
• HEAT repeat-containing protein (HEATR)

Component of

• target of rapamycin 1 complex (TORC1 complex)
• target of rapamycin 2 complex (TORC2 complex)

Database

• UniProt: http://www.uniprot.org/uniprot/P42345.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2475
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2475
• OMIM: https://mirror.omim.org/entry/601231