ribosomal protein S6 kinase beta-1; ribosomal protein S6 kinase I; S6K1; S6K; 70 kD ribosomal protein S6 kinase 1; p70 S6 kinase alpha; p70(S6K)-alpha; p70-S6K; P70S6K; p70-alpha (RPS6KB1, STK14A)

Function

• specifically phosphorylates ribosomal protein S6 in response to insulin or several classes of mitogens
• interacts with PPP1R9A/neurabin-1 (putative)
• activation by serine/threonine phosphorylation & protein kinase C
• inactivated by type 2A phosphatase
• apparently not a substrate for MAP kinase
• interacts with PPP1R9A/neurabin-1 (putative)

Structure

• belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
• contains 1 AGC-kinase C-terminal domain
• contains 1 protein kinase domain

Compartment

• cytoplasm, cell junction, synapse, synaptosome (putative)

Alternative initiation

Named isoforms=2

Expression

• widely expressed

More general terms

• ribosomal protein S6 kinase

Database

• UniProt: http://www.uniprot.org/uniprot/P23443.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6198
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6198
• OMIM: https://mirror.omim.org/entry/608938