sirolimus; rapamycin (Rapamune)

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Indications

Dosage

  • loading dose of 6 mg PO (15 mg/kg)
  • maintenance: 2 mg PO QD (1 mg/kg/day)
  • should be taken 4 hours after cyclosporine
  • mix with 60 mL of water or orange juice only

Solution: (oral)

  • 1 mg/mL (60 & 120 mL, or 1,2, 5 unit-of-use pouches)

topical 1%

Storage

Pharmacokinetics

Adverse effects

Drug interactions

*

* agents that may be administered without dose-adjustment of sirolimus:

Mechanism of action

Notes

More general terms

Additional terms

References

  1. 1.0 1.1 Lavin MF, Khanna KK, Beamish H, Spring K, Watters D, Shiloh Y. Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase. Trends Biochem Sci. 1995 Oct;20(10):382-3. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8533147 (G1 arrest)
  2. Kaiser Permanente Pharmacy update
  3. 3.0 3.1 Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  4. 4.0 4.1 Journal Watch 23(14):110, 2003 Lemos PA et al Early outcome after sirolimus-eluting stent implantation in patients with acute coronary syndromes: insights from the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) registry. J Am Coll Cardiol 41:2093, 2003 PMID: https://www.ncbi.nlm.nih.gov/pubmed/12798587
  5. 5.0 5.1 Miller T Proceedings of the 38th Annual Meeting of the American Aging Association: Integrative Biology: Hormones, Signaling, and Aging. May 29-June 1, 2009, Scottsdale, AZ
    Harrison DE et al Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009 Jul 8 http://dx.doi.org/10.1038/nature08221
  6. 6.0 6.1 FDA MedWatch http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm165731.htm
  7. FDA Medwatch http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm171828.htm
  8. FDA Medwatch Rapamune (sirolimus): Drug Monitoring Recommendations http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm197059.htm
  9. Deprecated Reference
  10. 10.0 10.1 10.2 10.3 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015

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