P-glycoprotein (gp170) or multidrug-resistance glycoprotein

Function

• P-glycoprotein 1 helps eliminate drugs by pumping them OUT of cells, back into the gut, bile, & urine for excretion
• P-glycoprotein 3 transports phosphatidylcholine

Pathology

• tumor cells may up-relate P-glycoprotein 1 as a mechanism for development of resistance to antineoplastic agents

Pharmacology

• inhibitors include:
  • antiarrhythmics: amiodarone, quinidine,
  • macrolides: clarithromycin, erythromycin
  • calcium channel blockers:
    • diltiazem, felodipine, nifedipine, verapamil
  • proton pump inhibitors: lansoprazole, omeprazole & others
  • SSRI: paroxetine, sertraline
  • others ciclosporin, colchicine, tamoxifen, ritonavir, danicopan

• inducers include rifampicin & St John's wort

More general terms

• transmembrane 12 protein
• adenosine triphosphatase (ATPase)
• glycoprotein
• carrier protein (transporter)

More specific terms

• ATP-binding cassette sub-family C member 12 (ATP-binding cassette C12, multidrug resistance-associated protein 9, ATP-binding cassette transporter sub-family C member 12, ABCC12, MRP9)
• P-glycoprotein 1 (PGY1, multidrug resistance protein 1, MDR1, gp170, ATP-binding cassette subfamily B member 1, ABCB1)
• P-glycoprotein 2 or multidrug resistance protein 2
• P-glycoprotein 3 (PGY3, multidrug resistance protein 3, MDR3, ATP-binding cassette subfamily B member 4, ABC4)