clarithromycin (Biaxin)

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Introduction

Tradename: Biaxin.

Indications

endocarditis prophylaxis prior to procedure

Dosage

Pharmacokinetics

elimination via liver

1/2life = 2-6 hours

Antimicrobial activity

Gram positive

Gram negative

Atypical bacteria

Anaerobes

* community-acquired resistant pneumococcus has been reported[6]

Adverse effects

Drug interactions

Laboratory

Mechanism of action

More general terms

Additional terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Sanford Guide to antimicrobial therapy 1997, 2001
  3. Harrison's Principles of Internal Medicine, 13th ed. Companion Handbook. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1995, pg 164
  4. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  5. 5.0 5.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 19. American College of Physicians, Philadelphia 1998, 2018.
  6. 6.0 6.1 Journal Watch 20(24):194, 2000 Kelley et al, Clin Infect Dis Oct 31:1008, 2000
  7. Prescriber's Letter 13(3): 2006 Cytochrome P450 drug interactions Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220233&pb=PRL (subscription needed) http://www.prescribersletter.com
  8. 8.0 8.1 Prescriber's Letter 12(9): 2005 Fatal Interaction Between Clarithromycin and Colchicine Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=211004&pb=PRL (subscription needed) http://www.prescribersletter.com
  9. 9.0 9.1 Prescriber's Letter 13(1): 2006 Clarithromycin mortality alert for patients with heart disease Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220110&pb=PRL (subscription needed) http://www.prescribersletter.com
  10. 10.0 10.1 Schembri S et al Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies. BMJ 2013;346:f1235 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23525864 <Internet> http://www.bmj.com/content/346/bmj.f1235
  11. 11.0 11.1 11.2 11.3 Deprecated Reference
  12. 12.0 12.1 Gandhi S et al Calcium-channel blocker - Clarithromycin Drug Interactions and Acute Kidney Injury. JAMA. Published online November 9, 2013 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24346990 <Internet> http://jama.jamanetwork.com/article.aspx?articleid=1769739
  13. 13.0 13.1 13.2 Svanstrom H et al Use of clarithromycin and roxithromycin and risk of cardiac death: cohort study. BMJ 2014;349:g4930 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25139799 <Internet> http://www.bmj.com/content/349/bmj.g4930
  14. 14.0 14.1 14.2 Li DQ, Kim R, McArthur E et al Risk of adverse events among older adults following co- prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4. CMAJ. Dec 22, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25534598 <Internet> http://www.cmaj.ca/content/early/2014/12/22/cmaj.140950.full.pdf+html
  15. 15.0 15.1 Wong AYS et al. Cardiovascular outcomes associated with use of clarithromycin: Population based study. BMJ 2016 Jan 13; 352:h6926 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26768836 <Internet> http://www.bmj.com/content/352/bmj.h6926
  16. 16.0 16.1 16.2 Paauw DS Dangerous and Deadly Drug Combinations Medscape. June 30, 2016 http://www.medscape.com/features/slideshow/dangerous-drug-combinations
  17. 17.0 17.1 Muanda FT, Sheehy O, Berard A Use of antibiotics during pregnancy and risk of spontaneous abortion. CMAJ 2017 May 1;189:E625-33 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28461374 <Internet> http://www.cmaj.ca/content/189/17/E625.full.pdf+html
  18. 18.0 18.1 Brooks M FDA Alert: Clarithromycin Risky in Patients With Heart Disease. Medscape - Feb 22, 2018. https://www.medscape.com/viewarticle/893025
    FDA Safety Alert. Feb 22, 2018 Clarithromycin (Biaxin): Drug Safety Communication - Potential Increased Risk of Heart Problems or Death in Patients With Heart Disease. https://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm597862.htm
  19. 19.0 19.1 Hung IF, Wu AK, Cheng VC et al Fatal interaction between clarithromycin and colchicine in patients with renal insufficiency: a retrospective study. Clin Infect Dis. 2005 Aug 1;41(3):291-300. Epub 2005 Jun 23. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16007523

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