solute carrier family 21 member 6; solute carrier organic anion transporter family member 1B1; liver-specific organic anion transporter 1; LST-1; OATP-C; Na+-independent organic anion-transporting polypeptide 2; OATP-2 (SLCO1B1, LST1, OATP1B1, OATP2, OATPC, SLC21A6)

Function

• mediates Na+-independent transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine & triiodothyronine
• may play a role in the clearance of bile acids & organic anions from the liver

Structure

• belongs to the organo anion transporter (TC 2.A.60) family
• contains 1 Kazal-like domain

Compartment

• basolateral cell membrane
• detected in basolateral membranes of hepatocytes

Expression

• highly expressed in liver
• not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon or leukocytes

Pathology

• myopathy related to SLCO1B1 variant

More general terms

• transmembrane 7c protein
• glycoprotein
• solute carrier family 21 (SLC21, SLC21A)
• organic anion transporting polypeptide (OATP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10599
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10599
• OMIM: https://mirror.omim.org/entry/604843
• UniProt: http://www.uniprot.org/uniprot/Q9Y6L6.html