hepatocyte
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Pathology
- polyploid* hepatocytes are compromised in their ability to divide
* transitions between diploid & polyploid hepatocytes are limited under homeostatic conditions
Physiology
- human diploid hepatocytes turnover throughout life
- average age of human hepatocyte is 3 years
More general terms
References
- ↑ Heinke P, Rost F, Rode J et al Diploid hepatocytes drive physiological liver renewal in adult humans. Cell Systems 2022. May 31 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35649419 https://www.cell.com/cell-systems/fulltext/S2405-4712(22)00171-5
- ↑ De Simone V, De Magistris L, Lazzaro D, Gerstner J, Monaci P, Nicosia A, Cortese R. LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBO J. 1991 Jun;10(6):1435-43. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1673925