organic anion transporting polypeptide (OATP)

Introduction

Family of drug transporters.

Function

• transport anions (including anionic drugs) into cells

Inhibition:

• inhibited by certain fruit juices including:
  • apple
  • orange
  • grapefruit

Expression

• expressed in GI tract, liver, kidney, & blood-brain barrier

More general terms

• carrier protein (transporter)

More specific terms

• organic anion transporting polypeptide 1 (Na+ independent organic anion transporter, OATP1, OATP-A, solute carrier family 21 member 3, SLC21A3, SLCO1A2)
• solute carrier family 21 member 11; solute carrier organic anion transporter family member 3A1; OATP3A1; organic anion transporter polypeptide-related protein 3; OATP-RP3; OATPRP3; organic anion-transporting polypeptide D; OATP-D; PGE1 transporter; Na+...
• solute carrier family 21 member 12; solute carrier organic anion transporter family member 4A1; OATP4A1; colon organic anion transporter; organic anion transporter polypeptide-related protein 1; OATP-RP1; OATPRP1; POAT; organic anion-transporting polyp...
• solute carrier family 21 member 14; solute carrier organic anion transporter family member 1C1; organic anion transporter F; OATP-F; organic anion transporter polypeptide-related protein 5; OAT-RP-5; OATPRP5; organic anion-transporting polypeptide 14; ...
• solute carrier family 21 member 6; solute carrier organic anion transporter family member 1B1; liver-specific organic anion transporter 1; LST-1; OATP-C; Na+-independent organic anion-transporting polypeptide 2; OATP-2 (SLCO1B1, LST1, OATP1B1, OATP2, O...
• solute carrier family 21 member 8; solute carrier organic anion transporter family member 1B3; liver-specific organic anion transporter 2; LST-2; organic anion transporter 8; organic anion-transporting polypeptide 8; OATP-8 (SLCO1B3, LST2, OATP1B3, OAT...
• solute carrier organic anion transporter family member 1B7; liver-specific organic anion transporter 3; LST-3 (SLCO1B7, LST3, LST3TM12)
• solute carrier organic anion transporter family member 6A1 (solute carrier family 21 member 19, organic anion-transporting polypeptide I, OATP-I, organic anion-transporting polypeptide 6A1, gonad-specific transporter, GST, cancer/testis antigen 48, CT4...