organic anion transporting polypeptide 1 (Na+ independent organic anion transporter, OATP1, OATP-A, solute carrier family 21 member 3, SLC21A3, SLCO1A2)

Function

• mediates the Na+-independent transport of organic anions such as sulfobromophthalein (BSP) & conjugated (taurocholate) & unconjugated (cholate) bile acids

Inhibition:

• selectively inhibited by naringin found in grapefruit

Structure

• belongs to the organo anion transporter (TC 2.A.60) family
• contains 1 Kazal-like domain

Compartment

membrane

Alternative splicing

named isoforms=2

More general terms

• solute carrier family 21 (SLC21, SLC21A)
• transmembrane 12e protein
• glycoprotein
• organic anion transporting polypeptide (OATP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6579
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6579
• OMIM: https://mirror.omim.org/entry/602883
• UniProt: http://www.uniprot.org/uniprot/P46721.html