solute carrier family 21 member 14; solute carrier organic anion transporter family member 1C1; organic anion transporter F; OATP-F; organic anion transporter polypeptide-related protein 5; OAT-RP-5; OATPRP5; organic anion-transporting polypeptide 14; OATP-14 (SLCO1C1, OATP14, OATPF, SLC21A14)

Function

• mediates Na+-independent high affinity transport of organic anions such as the thyroid hormones
  • thyroxine (T4)
  • reverse T3 (rT3)
• other potential substrates are transported with much lower efficiency
  • triiodothyronine (T3)
  • 17-beta-glucuronosyl estradiol
  • estrone-3-sulfate
  • sulfobromophthalein (BSP)

Structure

• belongs to the organo anion transporter (TC 2.A.60) family
• contains 1 Kazal-like domain

Compartment

membrane

Expression

• highly expressed in brain & in Leydig cells in testis
• detected in many brain regions
• not detected in pons or cerebellum

More general terms

• transmembrane 10 protein
• glycoprotein
• solute carrier family 21 (SLC21, SLC21A)
• organic anion transporting polypeptide (OATP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=53919
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:53919
• OMIM: https://mirror.omim.org/entry/613389
• UniProt: http://www.uniprot.org/uniprot/Q9NYB5.html