thyroxine (T4)
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Function
- thyroid hormones increase metabolic rate of tissues
- involved in regulation of growth & differentiation
Compartment
- plasma
- nearly all (> 99.9%) is bound one of the 3 major plasma thyroid hormone-binding proteins (thyroxine-binding globulin, prealbumin & albumin)
Expression
- T4 is formed (via activity of thyroid peroxidase) & stored as an iodinated residue of thyroglobulin
- normal thyroid gland makes 80 g of T4/day
Pharmacology
- levothyroxine is used for treatment of hypothyroidism
Pharmacokinetics
elimination via liver
Laboratory
- therapeutic range for levothyroxine is determined by normalizing serum TSH in patients with intact pituitary function[3] (see hypothyroidism)
More general terms
More specific terms
Additional terms
- dextrothyroxine (Cholixin)
- euthyroid hyperthyroxinemia
- free thyroxine index (fT4I)
- thyroglobulin; Tg (TG)
- thyroid peroxidase
- thyroxine [T4] (free) in serum
- thyroxine [T4] (total) in serum
- thyroxine-binding globulin; Serpin A7; T4-binding globulin (SERPINA7, TBG)
Component of
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ UniProt http://www.uniprot.org/uniprot/Q6IMI4.html
- ↑ 3.0 3.1 Medical Knowledge Self Assessment Program (MKSAP) 16, American College of Physicians, Philadelphia 2012