solute carrier family 21 member 12; solute carrier organic anion transporter family member 4A1; OATP4A1; colon organic anion transporter; organic anion transporter polypeptide-related protein 1; OATP-RP1; OATPRP1; POAT; organic anion-transporting polypeptide E; OATP-E; Na+-independent organic anion transporter E (SLCO4A1, OATP1, OATPE, SLC21A12)

Function

• mediates the Na+-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) & rT3, & of estrone-3-sulfate & taurocholate

Structure

• belongs to the organo anion transporter (TC 2.A.60) family
• contains 1 Kazal-like domain

Compartment

membrane

Alternative splicing

named isoforms=4

Expression

• widely expressed
• not expressed spleen or leukocytes

More general terms

• transmembrane 12 protein
• glycoprotein
• solute carrier family 21 (SLC21, SLC21A)
• phosphoprotein
• organic anion transporting polypeptide (OATP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=28231
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:28231
• OMIM: https://mirror.omim.org/entry/612436
• UniProt: http://www.uniprot.org/uniprot/Q96BD0.html