solute carrier family 21 member 11; solute carrier organic anion transporter family member 3A1; OATP3A1; organic anion transporter polypeptide-related protein 3; OATP-RP3; OATPRP3; organic anion-transporting polypeptide D; OATP-D; PGE1 transporter; Na+-independent organic anion transporter D (SLCO3A1, OATPD, SLC21A11)
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Function
- mediates Na+-independent transport of organic anions such as estrone-3-sulfat
- mediates transport of prostaglandins (PGE1 & PGE2, thyroxine (T4), deltorphin II, BQ-123 & vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal Tyr), estrone-3-sulfate, taurocholate, digoxin nor DHEAS
- KM=101 nM for PGE1 (isoform 1)
- KM=218 nM for PGE1 (isoform 2)
- KM=219 nM for PGE2 (isoform 1)
- KM=371 nM for PGE2 (isoform 2)
Structure
- belongs to the organo anion transporter (TC 2.A.60) family
- contains 1 Kazal-like domain
Compartment
- membrane
- in choroid plexus epithelium
- isoform 1 is localized at the basolateral membrane
- isoform 2 is localized at the apical membrane, as well as in the subapical intracellular vesicular compartments
Alternative splicing
named isoforms=4
Expression
- ubiquitous
- highly expressed in spleen & leukocytes
- generally, expression of isoform 1 is higher than that of isoform 2
- isoform 2 is particularly abundant in testis & brain
- in testis
- isoform 1 is
- detected in spermatogonia at different stages
- absent from Sertoli cells
- isoform 2 is
- present in both spermatogonia & Sertoli cells (at protein level)
- isoform 1 is
- expressed in choroid plexus epithelium
- differential expression of both isoforms is observed in various brain regions:
- choroid plexus epithelium
- isoform 1
- very abundant in the gray matter of frontal cortex
- not associated with neuronal cell bodies
- not detected in the white matter
- isoform 2
- associated with neuronal bodies & axons in both gray matter & white matter of the frontal cortex
More general terms
- transmembrane 12e protein
- glycoprotein
- solute carrier family 21 (SLC21, SLC21A)
- organic anion transporting polypeptide (OATP)
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9UIG8.html
- ↑ Nezu TI Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. PMID: https://www.ncbi.nlm.nih.gov/pubmed/10873595
- ↑ Huber RD et al Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain. Am J Physiol Cell Physiol. 2007 Feb;292(2):C795-806. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16971491