solute carrier family 21 member 8; solute carrier organic anion transporter family member 1B3; liver-specific organic anion transporter 2; LST-2; organic anion transporter 8; organic anion-transporting polypeptide 8; OATP-8 (SLCO1B3, LST2, OATP1B3, OATP8, SLC21A8)

Function

• mediates Na+-independent transport of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate & sulfobromophthalein (BSP)

Structure

• N-glycosylated
• belongs to the organo anion transporter (TC 2.A.60) family
• contains 1 Kazal-like domain

Compartment

• basal cell membrane
• lateral cell membrane
• detected in basal & lateral plasma membranes of hepatocytes

Expression

• highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein
• not detected in other tissues

Pathology

• highly expressed in some cancer cell lines derived from colon, pancreas, liver & gall bladder

More general terms

• transmembrane 12 protein
• glycoprotein
• solute carrier family 21 (SLC21, SLC21A)
• organic anion transporting polypeptide (OATP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=28234
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:28234
• OMIM: https://mirror.omim.org/entry/605495
• UniProt: http://www.uniprot.org/uniprot/Q9NPD5.html