complement-3 (C3)

^[1]^[2]^[3]

Introduction

Held in a strained configuration by thioester Cys-338 - Glu-341 in alpha chain; alpha & beta chains linked by disulfide bridge. Defects in complement C3:

↑ Tietz Fundametals of Clinical Chemistry 3rd ed, WB Saunders, 1987 pg 327
↑ Clinical Diagnosis and Management by Laboratory Methods, 18th ed, J.B. Henry (ed), W.B. Saunders, Philadelphia, PA, 1991 pg 832
↑ Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 497