glipizide (Glucotrol, Glucotrol XL)

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Introduction

Tradename: Glucotrol, Glucotrol XL. 2nd generation sulfonylurea.

Indications

management of diabetes mellitus type 2*

* may be preferred agent in patients with renal insufficiency

Dosage

Tabs: 5 & 10 mg.

**Doses > 10 mg/day may not provide additional benefit.

Pharmacokinetics

elimination via liver

elimination via kidney

protein binding = 92-99 %

1/2life = 7 hours

Adverse effects

Drug interactions

Laboratory

More general terms

Additional terms

Component of

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. 3.0 3.1 Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 470
  4. Geriatric Dosage Handbook, 6th edition, Selma et al eds, Lexi-Comp, Cleveland, 2001
  5. 5.0 5.1 Shorr RI, JAMA 279(18):1441-a, 1998 http://jama.ama-assn.org/cgi/content/full/279/18/1441-a
  6. Department of Veterans Affairs, VA National Formulary
  7. 7.0 7.1 Paauw DS Dangerous and Deadly Drug Combinations Medscape. June 30, 2016 http://www.medscape.com/features/slideshow/dangerous-drug-combinations

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