aplastic anemia

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Introduction

A group of disorders characterized by hematopoietic failure, peripheral pancytopenia, hypocellular bone marrow & the absence of malignant or myeloproliferative disorders.

Etiology

Pathology

Genetics

Clinical manifestations

Laboratory

Differential diagnosis

Management

More general terms

More specific terms

Additional terms

References

  1. Harrison's Principles of Internal Medicine, 13th ed. Companion Handbook, Isselbacher et al (eds), McGraw-Hill Inc. NY, 1995, pg 829-39
  2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 446-47
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 15, 16, 17. American College of Physicians, Philadelphia 1998, 2006, 2009, 2012, 2015
    Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
  4. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 672
  5. 5.0 5.1 Journal Watch 21(21):169, 2001
    Brodsky RA et al Durable treatment-free remission after high-dose cyclophosphamide therapy for previously untreated severe aplastic anemia. Ann Intern Med 135:477, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11578150
    Abkowitz J. Aplastic anemia: which treatment?. Ann Intern Med 135:524, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11578156
  6. Marsh JC, Ball SE, Cavenagh J et al Guidelines for the diagnosis and management of aplastic anaemia. Br J Haematol. 2009 Oct;147(1):43-70. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19673883
  7. Tichelli A, Schrezenmeier H, Socie G et al A randomized controlled study in patients with newly diagnosed severe aplastic anemia receiving antithymocyte globulin (ATG), cyclosporine, with or without G-CSF: a study of the SAA Working Party of the European Group for Blood and Marrow Transplantation. Blood. 2011 Apr 28;117(17):4434-41 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21233311
  8. 8.0 8.1 Townsley DM, Scheinberg P, Winkler T et al Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia. N Engl J Med 2017; 376:1540-1550. April 20, 2017 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28423296 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1613878
  9. 9.0 9.1 Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022

Patient information

Aplastic anemia patient information

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