lymphocytosis

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^[1]^[2]^[3]

Etiology

primary lymphocytosis
- lymphocytic malignancies
  - acute lymphocytic leukemia
  - chronic lymphocytic leukemia
  - prolymphocytic leukemia
  - hairy cell leukemia
  - adult T-cell leukemia
  - lymphoma
  - NK cell leukemia
  - T-gamma lymphocytosis
- monoclonal B-cell lymphocytosis*
  - multiple myeloma (plasmacytosis)^[3]
reactive lymphocytosis
- mononucleosis syndromes
- pertussis
- stress lymphocytosis (acute)
  - cardiovascular collapse
    - acute cardiac failure
    - myocardial infarction
    - septic shock
  - drug-induced
  - hypersensitivity reactions
  - major surgery
  - sickle cell crisis
  - status epilepticus
  - trauma
- persistent lymphocytosis (chronic)
  - autoimmune disorders
  - cancer
  - cigarette smoking
  - chronic inflammation
  - hyposplenism
  - polyclonal B-cell lymphocytosis
  - sarcoidosis
  - thymoma
  - Wegener's granulomatosis

* monoclonal B-cell lymphocytosis often occurs in asymptomatic patients who lack other criteria of chronic lymphocytic leukemia^[2]

More general terms

More specific terms

Additional terms

References

↑ Williams Hematology, 5th ed, Beutler et al (eds), McGraw Hill, NY, 1995, pg 964
↑ ^2.0 ^2.1 Medical Knowledge Self Assessment Program (MKSAP) 19 American College of Physicians, Philadelphia 2022
↑ ^3.0 ^3.1 Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022

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