hyposplenism

Introduction

(also see splenectomy)

Etiology

• congenital hyposplenism (Fanconi's syndrome)
• surgical splenectomy
• hyposplenism of old age
• splenic congestion
  • hemoglobinopathy
    • sickle cell disease
  • myeloproliferative disorder
    • essential thrombocytosis
    • myelofibrosis
• impaired vascular supply to the spleen
• immunological or autoimmune disorders
  • systemic lupus erythematosus
  • rheumatoid arthritis
  • systemic necrotizing vasculitis
  • sarcoidosis
  • graft versus host disease following bone marrow transplantation
  • IgA deficiency
  • thyroiditis
  • thyrotoxicosis
• gastrointestinal disease
  • celiac disease
  • dermatitis herpetiformis
  • ulcerative colitis
  • regional enteritis
  • intestinal lymphangiectasia
  • chronic active hepatitis
• malignancies
  • Sezary syndrome
  • multiple myeloma
  • gastric carcinoma
  • breast carcinoma
  • primary splenic angiosarcoma
  • non-Hodgkin's lymphoma
  • mastocytosis
• splenic irradiation
• drug induced
  • Thorotrast therapy
  • IV immunoglobulin
  • alpha-methyldopa
  • glucocorticoids
• systemic amyloidosis
• nephrotic syndrome
• splenic trauma
• disseminated Varicella

More general terms

• sign/symptom

Additional terms

• spleen
• splenectomy