intravenous immunoglobulin (Baygam, Octagam)

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Introduction

Pooled human IgG safe for intravenous administration.

Indications

Dosage

  • hypogammaglubulinemia:
    • start: 200 mg/kg IV monthly
    • increase to 300, 400 or 600 mg/kg, if clinical response (assessed by number of infections) is inadequate
    • larger doses have greater efficacy in children, but perhaps not in adults
  • dermatomyositis
    • 2000 mg/kg every 4 weeks (Octagam 10% solution)[3]
  • IM injectable solution (150 mg/mL): Baygam

Adverse effects

Mechanism of action

(postulated mechanisms)

More general terms

References

  1. 1.0 1.1 Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 15, 18. American College of Physicians, Philadelphia 1998, 2006, 2009, 2018.
  2. Intravenous Immunoglobulin: Prevention and Treatment of Disease http://consensus.nih.gov/cons/080/080_statement.htm
  3. 3.0 3.1 Ingram I FDA Approves IVIG for Dermatomyositis. Octagam 10% lands indication for adults following results of ProDERM trial. MedPage Today July 20, 2021 https://www.medpagetoday.com/rheumatology/generalrheumatology/93660
  4. NEJM Knowledge+ Allergy/Immunology