Kawasaki disease; mucocutaneous lymph node disease

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Introduction

Acute, febrile multisystem disease of children.

Etiology

Epidemiology

  • infants & children < 8 years of age
  • may occur in adults, especially those with HIV1

Pathology

Genetics

  • associated with defects in ITPKC

Clinical manifestations

Laboratory

Complications

Management

More general terms

References

  1. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 1678
  2. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 93, 1920
  3. 3.0 3.1 Wooditch AC, Aronoff SC. Effect of initial corticosteroid therapy on coronary artery aneurysm formation in Kawasaki disease: a meta-analysis of 862 children. Pediatrics. 2005 Oct;116(4):989-95. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16199713
  4. 4.0 4.1 Khasnis A and Langford CA. Update on vasculitis. J Allergy Clin Immunol 2009 Jun; 123:1226. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19501230
  5. 5.0 5.1 5.2 5.3 Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18, 19. American College of Physicians, Philadelphia 2009, 2012, 2015, 2018, 2022.
  6. Seve P, Stankovic K, Smail A et al Adult Kawasaki disease: report of two cases and literature review. Semin Arthritis Rheum. 2005 Jun;34(6):785-92. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15942913
  7. Gomard-Mennesson E, Landron C, Dauphin C et al Kawasaki disease in adults: report of 10 cases. Medicine (Baltimore). 2010 May;89(3):149-58 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20453601
  8. 8.0 8.1 8.2 8.3 8.4 Kole A, Chandakole D IMAGES IN CLINICAL MEDICINE. Strawberry Tongue. N Engl J Med 2015; 373:467. July 30, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26222562 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMicm1411222
  9. Scuccimarri R Kawasaki disease. Pediatr Clin North Am. 2012 Apr;59(2):425-45 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22560578
  10. 10.0 10.1 Chen S, Dong Y, Kiuchi MG et al Coronary Artery Complication in Kawasaki Disease and the Importance of Early Intervention A Systematic Review and Meta-analysis. JAMA Pediatrics. Oct 17, 2016 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27749951
    Sundel R. Clarifying the Role of Corticosteroids in Kawasaki Disease. JAMA Pediatr. 2016 Oct 17 PMID: https://www.ncbi.nlm.nih.gov/pubmed/27749946
  11. Cohen E, Sundel R. Kawasaki Disease at 50 Years. JAMA Pediatr. 2016 Sep 26. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27668809
  12. 12.0 12.1 12.2 12.3 12.4 12.5 12.6 Rashid RM, Barros BS (image) Hidden Heart Disease: 19 Dermatologic Clues You Should Know. Medscape. June 13, 2017. http://reference.medscape.com/slideshow/hidden-heart-disease-6004452
  13. Alikhan M, Lohr KM (images) Kawasaki Disease: Do You Know the Signs? Medscape. Sept 27, 2017 http://reference.medscape.com/slideshow/kawasaki-disease-6005698
  14. McCrindle BW, Rowley AH, Newburger JW et al Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation. 2017 Apr 25;135(17):e927-e999. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28356445
  15. 15.0 15.1 15.2 15.3 15.4 NEJM Knowledge+
    Sundel RP Kawasaki disease Rheum Dis Clin North Am. 2015;41(1):63-73 PMID: https://www.ncbi.nlm.nih.gov/pubmed/25399940
    Mirza SJ, Mohammed KO, Baslaib FO. Myocardial infarction in a young man due to coronary artery aneurysms after an undiagnosed Kawasaki disease. J Emerg Med. 2014 Jun;46(6):763-6 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24565879

Patient information

Kawasaki disease patient information

Database