hairy cell leukemia (leukemic reticuloendotheliosis)

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Introduction

Named for appearance of neoplastic B-cells with hairy projections* seen on smear preparations.

* described as atypical lymphoid cells with radial projections in[9]

Pathology

Immunophenotype

B cell antigens (CD19, CD20, CD22, CD79a) +, sIg+ (M +/- D, G or A), CD11c+, CD25+, CD103+, CD5-, CD10-, CD23-

Genetics

  • Ig heavy & light chain genes rearranged
  • overexpression of RGS1

Clinical manifestations

Laboratory

Complications

Management

More general terms

Additional terms

References

  1. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994 Sep 1;84(5):1361-92. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8068936
  2. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 539
  3. WHO Classification Tumours of Haematopoietic and Lymphoid Tissues. IARC Press 2001
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18, 19. American College of Physicians, Philadelphia 2009, 2012, 2015, 2018, 2021.
    Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022
  5. Allsup DJ, Cawley JC. The diagnosis and treatment of hairy-cell leukaemia. Blood Rev. 2002 Dec;16(4):255-62. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12350368
  6. Else M, Ruchlemer R, Osuji N et al Long remissions in hairy cell leukemia with purine analogs: a report of 219 patients with a median follow-up of 12.5 years. Cancer. 2005 Dec 1;104(11):2442-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16245328
  7. 7.0 7.1 7.2 7.3 7.4 Anello J, Feinberg B, Lindsey R et al Hairy Cell Leukemia National Comprehensive Cancer Network Clinical Practice Guidelines, December 2017 Medscape. Dec 6, 2017 https://reference.medscape.com/viewarticle/889632_4
    Wierda WG, Byrd JC, Abramson JS, et al. Hairy Cell Leukemia, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology. Natl Compr Canc Netw. 2017 Nov;15(11):1414-27. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29118233 <Internet> http://www.jnccn.org/content/15/11/1414.long
  8. Getta BM, Park JH, Tallman MS. Hairy cell leukemia: Past, present and future. Best Pract Res Clin Haematol. 2015 Dec;28(4):269-72. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26614906 Free PMC Article
  9. 9.0 9.1 9.2 9.3 NEJM Knowledge+ Hematology
    Troussard X, Cornet E. Hairy cell leukemia 2018: Update on diagnosis, risk-stratification, and treatment. Am J Hematol. 2017 Dec;92(12):1382-1390 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29110361 PMCID: PMC5698705 Free PMC article
  10. Hairy Cell Leukemia (PDQ): Treatment http://www.nci.nih.gov/cancertopics/pdq/treatment/hairy-cell-leukemia/HealthProfessional

Patient information

hairy cell leukemia patient information