B cell markers

Introduction

Include:

• CD10 (pre-B cells, germinal center cells, neutrophils, pre-B ALL, Burkitt lymphoma and follicular lymphoma)
• CD19 (appears early in B cell differentiation and persists through maturation until plasma cell stage; need frozen tissue),
• CD20 (appears later in B cell maturation and persists until plasma cell stage),
• CD21, CD22 (expressed at later stages of maturation)
• CD23 (follicular dendritic reticulum cells, sIgM/sIgD double positive B cells and small lymphocytic lymphoma
• CD25 (small lymphocytic lymphoma, mantle cell lymphoma)
• CD34 & TdT (very immature cells)
• CD43 (activated B cells, T cells, neutrophils) low grade B cell lymphomas except follicular lymphoma)
• CD79a (B precursor cells before CD19, stops before plasma cell stage)
• HLA-DR, Fc receptors, complement receptors