CD25; interleukin-2 receptor alpha chain; IL-2 receptor alpha subunit; IL-2-RA; IL2-RA; p55; TAC antigen (IL2RA)
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Function
- low-affinity receptor for interleukin-2
- insufficient alone for transducing signal of IL-2
Structure
contains 2 Sushi (CCP/SCR) domains
Compartment
membrane
Pathology
- genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10)
More general terms
Additional terms
- basiliximab (Simulect)
- interleukin-2 receptor alpha in serum
- interleukin-2; IL-2; T-cell growth factor; TCGF (IL2)
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/P01589.html
- ↑ IL2RAbase; Note: IL2RA mutation db http://bioinf.uta.fi/IL2RAbase/
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/il2ra/
- ↑ Saltzman EM, Luhowskyj SM, Casnellie JE. The 75,000-dalton interleukin-2 receptor transmits a signal for the activation of a tyrosine protein kinase. J Biol Chem. 1989 Nov 25;264(33):19979-83. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2511197
- ↑ Takeshita T et al Cloning of the gamma chain of the human IL-2 receptor. Science. 1992 Jul 17;257(5068):379-82. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1631559
Database
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3559
- OMIM: https://mirror.omim.org/entry/147730
- OMIM: https://mirror.omim.org/entry/601942
- OMIM: https://mirror.omim.org/entry/606367
- UniProt: http://www.uniprot.org/uniprot/P01589.html
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3559