CD43; leukosialin; leukocyte sialoglycoprotein; sialophorin; galactoglycoprotein; GALGP (SPN)
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Function
- one of the major glycoproteins of thymocytes & T-cells
- role in the physicochemical properties of the T-cell surface
- role in lectin binding, presents carbohydrate ligands to selectins
- counter receptor for CD169 (putative)
- during T-cell activation is actively removed from the T-cell to antigen-presenting cell contact site, thus a negative regulatory role in adaptive immune response (putative)
- interacts with HIPK2 via the cytoplasmic domain
Structure
- has an extended rodlike structure that could protrude above the glycocalyx of the cell & allow multiple glycan chains to be accessible for binding
- glycosylated, has a high content of sialic acid & O-linked carbohydrate structures
Compartment
membrane
Expression
- T cells
- activated B cells
- NK cells
- granulocytes
- monocytes
- megakaryocytes
- brain
Pathology
- expressed in:
- T cell lymphomas ~80%
- coexpressed with CD20 in small lymphocytic lymphoma
- granulocytic sarcomas
- AML
- ALL (most)
- plasmacytomas
- mast cell disease
- defective expression seen in Wiskott-Aldrich syndrome
More general terms
Additional terms
References
- ↑ Wong RC, Remold-O'Donnell E, Vercelli D, Sancho J, Terhorst C, Rosen F, Geha R, Chatila T. Signal transduction via leukocyte antigen CD43 (sialophorin). Feedback regulation by protein kinase C. J Immunol. 1990 Feb 15;144(4):1455-60. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2137493
- ↑ Cyster JG, Shotton DM, Williams AF. The dimensions of the T lymphocyte glycoprotein leukosialin and identification of linear protein epitopes that can be modified by glycosylation. EMBO J. 1991 Apr;10(4):893-902. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/1706994
- ↑ <Internet> http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ UniProt http://www.uniprot.org/uniprot/P16150.html