selectin

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Introduction

A family of Ca+2-dependent (C-type) mammalian lectins found on cells of the vascular system. Selectins are important for adhesion of leukocytes to endothelial cells during flow because of rapid on/off rates of binding. Integrins are more important for leukocyte adhesion during stasis because of higher binding affinities.

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References

  1. Springer TA, Lasky LA. Cell adhesion. Sticky sugars for selectins. Nature. 1991 Jan 17;349(6306):196-7. No abstract available. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1987472
  2. Chien, S, Molecular & mechanical bases of leukocyte-endothelial adhesion. Seminar, University of Mississippi Medical Center, Jan. 12, 1993