CD62E, E-selectin; endothelial leukocyte adhesion molecule 1; ELAM-1; leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD62 antigen-like family member E (SELE, ELAM1)
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Function
- cell-surface glycoprotein with a role in immunoadhesion
- mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG
- may have a role in capillary morphogenesis
- interacts with PSGL1/SELPLG through the sialyl Lewis X epitope; PSGL1 sulfation appears not to be required for this interaction
- recognizes sialylated fucosylated ligand (CD65) on leukocytes
- mediates binding to leukocytes in:
- inflammatory sites
- atherosclerosis
- tumor cell adhesion in metastasis
Structure
- belongs to the selectin/LECAM family
- contains 1 C-type lectin domain
- contains 1 EGF-like domain
- contains 6 Sushi (CCP/SCR) domains
Compartment
membrane
Expression
- cytokine induced endothelial cells
Polymorphism
- polymorphism Ser-149 -> Arg-149 is associated with a higher risk of coronary artery disease (CAD)
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P16581.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/sele/
- ↑ Functional glycomics gateway - glycan binding: E-selectin http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_233
- ↑ http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002